WormBase-Caltech Weekly Calls

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July 6, 2017

Noctua

  • Use for all literature curation in future?
  • We would need to see how it could be used for all data types
  • We would also want a full-time developer working on Noctua; maybe bring Juancarlos into the project

SPELL

  • SPELL related data - how to deal with?
    • Data: recalculated, mapping, results dependent on SPELL
    • Analysis (clustering tool): clunky, freezes w/limited resources
  • Wen will work with Juancarlos to generate a SimpleMine-like tool for downloading data sets
  • Wen has to remove log files to make space on machine
  • ~360 data sets
  • Current virtual machine has 10G memory; is becoming limiting
  • SPELL has lots of dependencies; difficult to account for them all when building SPELL
  • Would be good if we could setup a new (larger) virtual machine to run SPELL; how much time/resources do we want to spend on it?

Micropublications

  • Poster at Zebrafish meeting pointing to micropublications
  • Microarray micropublications? Unpublished results
  • Can make links to GEO submissions
  • Daniela and Karen can draw up a mock publication to look at as a template

Community Curation

  • Considering sending requests to only one person, first author when have info
  • This should allow for more emails to be sent out per week, and more submissions, even if we maintain the 16% response rate
  • Chris will work with Juancarlos once he's back from vacation
  • What's next data type? Interactions? Site of action? Anatomy?
  • What's required for site of action? Phenotype, gene, cell/tissue where gene is introduced or removed
  • Can send requests to lab heads to fill in phenotype info for alleles from their lab

Linking

  • Will human genes link to AGR human gene pages? Gene Cards? HGNC?


July 13, 2017

Allele attribute assignment

  • Some attributes of alleles are currently only assigned in the context of a phenotype annotation
  • Many times these attributes are reported independently of a phenotype experiment
  • It would be good to have a mechanism to curate these attributes to alleles independent of phenotype curation
  • As far as modeling goes I (Chris) had intended to do dump these attributes directly into the ?Variation object like this:
?Variation   Null  ?Phenotype_experiment
  • This would allow us to always point to a ?Phenotype_experiment object as a container of evidence, but if we don't always have a ?Phenotype_experiment object to point to then maybe a better approach is just to reference the paper like this:
?Variation  Null  ?Paper
  • This would require a separate curation pipeline from phenotype to capture these attributes; will discuss more with Mary Ann when she's back from vacation

Phenotype form submission requests

  • Originally we sent email requests independently of Author First Pass pipeline emails
  • Now a link to phenotype form is being included in Author First Pass emails, and we're putting a hold on all new email requests to corresponding author for one month
  • I (Chris) am considering returning to original approach of sending requests independently of AFP, to see if we can get response rate up at all