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November 2, 2017

Site visits

• Invited to give 25+5 minute talk at Worcester Area Worm Meeting on November 14th
• Had particular interest in micropublications
• 25-30 minutes probably insufficient to present everything that we want
• Also, fairly short notice
• Travel budget?
• Would be good to meet with individual labs and lab members to discuss WormBase
• Will probably decline this offer and wait until a longer talk next year
• Will point them to micropublication.org to find out more info
• Maybe Karen/Daniela could do a webinar during the Nov 14 slot

GO annotation for Expression cluster

• Wen asking about some GO annotation details for expression clusters
• Want to annotate a particular data set with a GO term
• Wen will discuss with Kimberly

Tazendra issue

• Had a problem Sunday-Monday
• We should consider moving curation database to a new machine/location and/or creating a backup system
• Move to the cloud? Would reduce maintenance time but will add cost
• Install on different local server?
• What are the requirements? Disk space? Computation?

Marker help desk question

• Someone looking for promoter sequences of pan-neuronal genes; neuronal marker
• Can go to "neuron" anatomy page and search expression patterns table for the term "marker"; not optimal
• Can also (reverse) sort the "Expression Pattern" column of table to pull up "Marker" annotations
• Create a "Markers" widget? "Tissue Marker" or "Expression Marker"? Daniela will create ticket
• Existing markers in Associations widget will remain there
• Are markers still being curated?

November 9, 2017

AGR disease working group update

• Next focus, for AGR 1.3 release in March 2018, is to pull allele objects with basic info into AGR
• First we will only pull in alleles that have disease data and that only have associations to a single gene
• Basic allele information will be provided on respective AGR gene pages in an Alleles table, along with associated disease data (?)
• Alleles may also be referenced within a gene page disease table
• Disease pages will show Association tables with alleles in addition to genes
• In both contexts, alleles will link to the MOD allele page (until AGR develops an allele page)
• Alleles will be added to the disease association file (DAF) and respective JSON files
• Dedicated AGR allele pages will come at a later release, probably as a work product of the AGR Variants working group
• We will want to work closely with the AGR Variants working group
• Alleles will be stepping stone to other genotype components and then complex genotypes, as well as treatments/conditions/chemicals etc.
• Also discussed the possibility of a Disease ribbon, showing diseases in AGR orthologs
• If we show disease associations inferred by orthology, we need to be explicit about evidence codes and data provenance; maybe different tables for experimental versus inferred associations?

Help Desk question: finding all alcohol dehydrogenase genes

• There is no single root "alcohol dehydrogenase" term in the GO MF branch, but many more specific terms that exist in different branches
• This means that one has to search for terms that explicitly have "alcohol dehydrogenase" in the name of the term and cannot take advantage of the Ontology Browser to see all gene associations, direct and inferred
• This approach also will miss terms like "methanol dehydrogenase" or other logical descendant terms
• Also, can search for protein domains/motifs that explicitly have "alcohol dehydrogenase" in the name of the motif, but domains are not (as far as I'm aware, in InterPro or PFAM at least) organized into an ontology

Alliance/AGR interactions working group

• Now formed, first meeting tomorrow (Friday Nov 10th) at 1pm PST/4pm EST
• Can find folder and related documents in the Alliance "Working Groups" Google folder