Difference between revisions of "WormBase-Caltech Weekly Calls"
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*Tag the Expression Cluster with applicable WormBase build/release for reference | *Tag the Expression Cluster with applicable WormBase build/release for reference | ||
*Capture treatment conditions (temperature, molecules, pathogens, etc.) | *Capture treatment conditions (temperature, molecules, pathogens, etc.) | ||
+ | |||
+ | |||
+ | |||
+ | == August 4, 2011 == | ||
+ | |||
+ | Leak in office | ||
+ | *Emergency showers don't necessarily have drains | ||
+ | *We need to make sure that things in offices are prepared for potential water leaks | ||
+ | *Production server still running | ||
+ | *Mangolassi down for the time being; will be back up when dry | ||
+ | *Should call physical plant 24-hour emergency line (ext. 4717) | ||
+ | *Feel free to check offices/labs above ours to assess risk of leak | ||
+ | |||
+ | |||
+ | Testing concise description OA on sandbox | ||
+ | *Community annotation form needs to be very simple (e.g. gene name and empty box only) | ||
+ | |||
+ | |||
+ | Transgenomics pictures | ||
+ | *Daniela spoke with Mihail about getting pictures from their database | ||
+ | *We should know exactly what the clone is (sequence) | ||
+ | *What are they using for anatomy annotation? | ||
+ | *Linking to Yuji Kohara's database (NEXTDB)? | ||
+ | |||
+ | |||
+ | Gene file from Hinxton to populate Gene Tables | ||
+ | *Kimberly working with Mary Ann Tuli and Michael Paulini to make sure each gene names are cleaned up | ||
+ | |||
+ | |||
+ | Raymond | ||
+ | *Trying to install Amigo (for Ontology browsing) | ||
+ | *Working on SPELL | ||
+ | |||
+ | |||
+ | SVM | ||
+ | *Karen using author first pass list for priority | ||
+ | *2 out of 3 papers have not been flagged for phenotype; Why? | ||
+ | *Michael setup a way to tag papers on Textpresso Dev if they've been processed by SVM | ||
+ | *How do we make sure all papers go through SVM pipeline? | ||
+ | |||
+ | |||
+ | Replacing power supply on conference phone | ||
+ | *Probably cannot fix | ||
+ | *Need to buy new one |
Revision as of 16:36, 4 August 2011
2011 Meetings
July 7, 2011
Root Passwords for all machines
- Send to Paul for emergency access
Issue Trackers
- All code in production use in BitBucket or equivalent
- Textpresso - Subversion (code can be shared)
- WormBase - Bitbucket, GitHub (can commit code)
- Todd says Github for code is best
Alex Bishop Help Desk E-mail
- Interolog Finder
- FlyBase will include links soon
- Is WormBase interested connecting to it?
- Can it be sustainably maintained?
- We should make a link under the Tools section of WormBase
- Interolog Finder provides cytoscape files
- Does Cytoscape have a web interface?
Elbrus is currently working stably
- Raymond stabilized Elbrus
- Elbrus is a frankenstein now
- Sanger/EBI taking over the RNAi mappings
- Will discuss with Igor once we determine the remaining issues
- Elbrus still needed for RNAi scripts to generate ACE files
Oliver Hobert correcting expression patterns occasionally
- Ask Oliver to point out what is missing
- Also ask Shawn Lockery
- Cell-specific markers
- Curated as transgenes
- Can link to specific promoters if transgenes present
- Bottom of every transgene page has a link to the static Marker table
- Check on new Beta version of WormBase website
Changing language of e-mail to authors to confirm data
- Non-nematode papers in WormBase via Cecilia?
- Authors sending all papers in their CV
Expression Cluster data curation
- Including GO terms, life stage, etc.
- Link to process pages?
Expression Cartoons
- Attempting to depict expression patterns by separate images for each tissue
- Would be nice to have a consolidated image with the option to expand to see individual tissue images
- Will maintain consolidated and expandable images for each gene as well as each expression pattern for each gene
- Trying to capture "Certain", "Uncertain", and "Partial" curation tags
Molecule curation
- Will need a molecule page on WormBase at some point
- Need a way to handle molecules that do not have a Mesh IDs
- Will replace WBMolecule IDs with Mesh IDs when they become available
- WBMolecule ID will be made a synonym of the molecule name alongside the Mesh ID
- Need to consider how the data will be stored and referred to in the long term (via ACE files etc.)
July 14, 2011
Concise descriptions
- OA being developed for concise descriptions
- Wiki page for concise descriptions
- User Community involvement - individual user curation/annotation
Diseases
- Managing disease relevance tags in appropriate models
- Relating human disease genes to C. elegans orthologous genes
- Developing an integrated view for users to browse human disease relevance
- Manual vs Automated curation processes
Worm Breeder's Gazette mass e-mails
- Users complained about e-mails going to old e-mail addresses
- Will only e-mail the most current e-mail on a user's profile
GitHub
- WormBase curation repository
- Should Juancarlos put postgres (and other) cgi's there?
- Make a separate Tazendra repository?
- Generate symbolic links for flat files (non-code)?
- Are we limited in the number of repositories we can have? Cost-dependent
- We could pay more for more repositories; is it worth it?
- Make another account separate from Todd's? Probably not; should keep consolidated in one account
- Do different dependencies cause problems?
- We will ask Todd about what he thinks is best
- OA code could eventually go to GitHub as well Code already in github -- J
- Textpresso code can go to GitHub as well
Ontology Browser
- Aldrin installing Amigo
- How long should installing Amigo take?
- Get some input from GO Consortium
Genetic Interactions from Textpresso
- Where are relevant paper sentences stored? on tazendra /home/postgres/work/pgpopulation/genegeneinteraction/<date>/ggi_<something> -- J
- Should we pull out sentences used by Andrei for interactions curation?
- Alternatively, redo a Textpresso search for relevant gene names, etc.
- Can we adequately find allele information?
Interolog Finder
- How to incorporate Interolog Finder into relevant gene pages?
- Maybe make a database object for each C. elegans Interolog Finder interaction
- Can we display our own data in Cytoscape? Interolog Finder data?
- Are Wei-wei's data being updated?
Rearrangements
- Want to change the variation auto-complete file
- Dead allele objects
- Problem: some Rearrangment objects are considered alleles/variations, others are dead or are not considered alleles
- How do we define/distinguish between Rearrangements/Deficiencies and Alleles?
- All are variations
- Do we make alleles and rearrangements mutually exclusive?
- Since all are variations, we handle each generically as a WBVar### object
- The distinction would just need to be made at the point of object creation
Anatomy Ontology
- Obsolete terms dumped from the Anatomy Ontology
- Will flag obsolete terms or try to remove from dump
July 28, 2011
Condition Form
- No one is using
- Juancarlos will remove
Concise Description OA
- Almost done
- Can this be of use for other nematode (other species) groups?
- Those studying other nematode are collecting functionally relevant information for genes
Life Stage tags
- Do we need a species tag for Life Stages?
- How closely do different nematode species have similar or the same life stages (and stage names)?
- Example, Infective Juveniles (IJs) (analogous to dauer?)
- Example, are all "L1"s the same across species?
- Let's leave out the species tag for now
Tracking Gene Name Changes
- Juancarlos fixed script for tracking and updating gene names in the OA
- Names will still not be updated (in the OA) until the new release, so there will be a lag
- Solution for now is to look up WBGeneID in WormBase and query the OA using that
- (This came up because the official name of a gene changed and the OA hadn't caught up yet)
Concise Description records with no genes?
- Some invalid genes disappeared from the name server all together, but should have stayed in tagged as "obsolete"
Author First Pass forms for transgene
- Overexpression phenotype
- Transgene phenotype
Streamlining Molecule curation
- Karen gave Michael a list of molecules to run through Textpresso
- Can save sentences related to molecules
GSA
- FlyBase linking moving forward
- GO-term linking
- 3 Papers have come through pipeline
- Curators will discuss once gone through
Outline for NAR paper in the works
WormBase paper for "Worm" journal
- "Fun" paper
- Discuss who we are and what is being done
Worm Breeder's Gazette
- WormBase can use Worm Breeder's Gazette as a forum for discussion
- We should have a presence for every Gazette
- Replacement for the news letter?
- SPELL related article? Virtual Worm?
SVM
- Ruihua will be here until late September
- We have an opportunity to update and tighten up the SVM code/process
- FlyBase interested in implementing
- Will take some effort to convert for fly
Expression Cluster Model
- Last week Wen finished processing Array Express microarray data
- Not a problem to keep up importing data from Array Express and GEO into SPELL
- Some authors do not provide spot IDs or respond to e-mails
- Gene IDs used rather than spot IDs
- New model will accommodate data from RNA-seq and tiling arrays (not just microarrays)
- Tag the Expression Cluster with applicable WormBase build/release for reference
- Capture treatment conditions (temperature, molecules, pathogens, etc.)
August 4, 2011
Leak in office
- Emergency showers don't necessarily have drains
- We need to make sure that things in offices are prepared for potential water leaks
- Production server still running
- Mangolassi down for the time being; will be back up when dry
- Should call physical plant 24-hour emergency line (ext. 4717)
- Feel free to check offices/labs above ours to assess risk of leak
Testing concise description OA on sandbox
- Community annotation form needs to be very simple (e.g. gene name and empty box only)
Transgenomics pictures
- Daniela spoke with Mihail about getting pictures from their database
- We should know exactly what the clone is (sequence)
- What are they using for anatomy annotation?
- Linking to Yuji Kohara's database (NEXTDB)?
Gene file from Hinxton to populate Gene Tables
- Kimberly working with Mary Ann Tuli and Michael Paulini to make sure each gene names are cleaned up
Raymond
- Trying to install Amigo (for Ontology browsing)
- Working on SPELL
SVM
- Karen using author first pass list for priority
- 2 out of 3 papers have not been flagged for phenotype; Why?
- Michael setup a way to tag papers on Textpresso Dev if they've been processed by SVM
- How do we make sure all papers go through SVM pipeline?
Replacing power supply on conference phone
- Probably cannot fix
- Need to buy new one