Drugs

C. elegans as a model system to study drugs

C. elegans is being used to study:

• metal toxicity and detoxification
• the effects of a drug/chemical on disease phenotypes
• identify gene targets for a given drug/chemical
• mode of action of a drug/chemical (MOA)

Types of drugs being studied include:

• Antifungal agents
• Antimicrobial agents
• Antiparasitic drugs--Aldicarb, Ivermectin, Levamisole
• Anti-depressants--Fluoxetine, Imipramine
• Anaesthic--Halothane
• Anticancer drugs--Farnesyltransferase inhibitors (FTIs)
• Anticonvulsants--Ethosuximide, Arimethadione
• Alkaloid drugs--Nicotine
• Immunosuppressants--Prednisone
• Nutritional supplements--Resveratrol, Gingko biloba
• Opioid toxins--MPTP/MPP+
• Pychoactive drug--Ethanol