LEGO Curation
From WormBaseWiki
Contents
Agenda
Logins
- Everyone set up okay?
LEGO Principles
- Pieces of biological information are connected using a controlled vocabulary of relations
- Assertions made using these relations are supported with evidence statements, i.e. ECO codes, references
- LEGO models are 'models of instances' meaning that these are models of specific individuals and events
LEGO at its Most Basic
- Molecular functions are enabled_by genes/gene products
- Molecular functions may be part_of larger biological processes
- Molecular functions occur_in some location
- Subcellular locations are part_of some larger anatomical structure
LEGO Beyond Basics
- Some biological processes and molecular functions regulate other biological processes
- The regulation may be positive or negative and may be 'direct' or 'indirect'
- Some biological processes and molecular functions are causally upstream of other biological processes
- Sometimes you don't know how two things are related - 'causally upstream of or within'
Paper for Curation
- The Intestinal Copper Exporter CUA-1 Is Required for Systemic Copper Homeostasis in Caenorhabditis elegans. PMID:27881675
- The entities:
- cua-1 (WBGene00000834)
- WP:CE26305 CUA-1, isoform a, 1238 aa
- WP:CE19271 CUA-1, isoform b, 1116 aa
- cuc-1 (WBGene00000835)
- pgp-2 (WBGene00003996)
- cua-1 (WBGene00000834)