Curation Scenarios for new GO Model - GPAD and .ace Representations
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Different Types of GO Annotations in GPAD File from UniProtKB
- WormBase - manual annotation, no extra information
- WormBase - manual annotation, entry in With/From column
- WormBase - manual annotation, entry in Annotation Extension column
- WormBase - manual annotation, isoform-specific annotation
- WormBase - manual annotation, use of ND evidence code and GO_REF
- WormBase - manual annotation, including interacting taxon
- WormBase - manual annotation, same GO term and evidence code but different papers
- WormBase - manual annotation, multiple annotations from a single paper
- WormBase - manual annotation, use of qualifier
- WormBase - manual annotation, multiple additional columns (e.g., With/From and Annotation Extension)
- UniProtKB - manual annotation, no extra information
- WormBase and UniProtKB - exact same manual annotation
- IntAct - manual protein binding annotation (Question: How many of these annotations have a more granular annotation from WB?)
- PAINT - annotation from phylogenetic inference
- Function-Process Links - annotations inferred by GOC based on inter-ontology relationships
- Phenotype2GO Pipeline - Variation Phenotype2GO
- Phenotype2GO Pipeline - RNAi Phenotype2GO (Notes: remove secondary targets, remove non-WT background as these are likely to be IGI, rather than IMP annotations?)