Difference between revisions of "WormBase-Caltech Weekly Calls"

From WormBaseWiki
Jump to navigationJump to search
(198 intermediate revisions by 11 users not shown)
Line 18: Line 18:
  
 
[[WormBase-Caltech_Weekly_Calls_2018|2018 Meetings]]
 
[[WormBase-Caltech_Weekly_Calls_2018|2018 Meetings]]
 +
 +
[[WormBase-Caltech_Weekly_Calls_2019|2019 Meetings]]
  
  
 
GoToMeeting link: https://www.gotomeet.me/wormbase1
 
GoToMeeting link: https://www.gotomeet.me/wormbase1
  
 +
= 2020 Meetings =
 +
 +
[[WormBase-Caltech_Weekly_Calls_January_2020|January]]
 +
 +
[[WormBase-Caltech_Weekly_Calls_February_2020|February]]
 +
 +
[[WormBase-Caltech_Weekly_Calls_March_2020|March]]
 +
 +
[[WormBase-Caltech_Weekly_Calls_April_2020|April]]
 +
 +
 +
 +
== May 7, 2020 ==
 +
 +
=== Alliance COVID Page ===
 +
* Available on stage
 +
* Textpresso for Coronavirus up for testing
 +
 +
=== SimpleMine at Alliance ===
 +
* Still some confusion about what it is
 +
* Will try to help clarify on PI meeting on Friday
 +
 +
=== Development environment for Alliance work ===
 +
* Raymond and Juancarlos have been working on
 +
* Existing hardware is strained; set up virtual machine
 +
* Still some technical issues
 +
 +
=== Open Publishing Festival ===
 +
* Later this month
 +
* Micropublications involved
 +
* Organized by the Collaborative Knowledge Foundation
 +
* Will involve publishers of books, journals, etc.
 +
* Will have a MOD-focused event, would be good to have WB curators participate/attend
 +
* Open to all
  
= 2019 Meetings =
+
=== Genotype class ===
 +
* Ranjana finished populating the Genotype OA with genotypes needed for disease curation
 +
* Will need to keep in mind that we will have a mapping pipeline to determine which genes are involved for a variation
 +
* There could end up being a discrepancy between an original or published name of a genotype and the components that are inferred by WormBase
 +
* Would be good to be clear/transparent about which components were automatically inferred
  
[[WormBase-Caltech_Weekly_Calls_January_2019|January]]
+
=== WS277/278 ===
 +
* Pipelines are pushed back by about 14 days/2 weeks
  
[[WormBase-Caltech_Weekly_Calls_February_2019|February]]
 
  
[[WormBase-Caltech_Weekly_Calls_March_2019|March]]
+
==May 13, 2020==
  
[[WormBase-Caltech_Weekly_Calls_April_2019|April]]
+
=== SURF students ===
 +
* Welcome Fernando!
 +
* Will work on neuron function with respect to dauer formation
  
[[WormBase-Caltech_Weekly_Calls_May_2019|May]]
+
=== Progress Report ===
 +
* Review Google Doc from Paul to make sure you're latest updates are there
 +
* Doc here: https://docs.google.com/document/d/1f3ettnkvwoKKiaAA4TSrpSQPEF7FmVVn6u2UdflA_So/edit?usp=sharing
  
[[WormBase-Caltech_Weekly_Calls_June_2019|June]]
+
===Genotype class===
 +
*Have 27 genotypes in the genotype OA, dumper and test .ace file ready
 +
*Will test ace file in citace as soon as we get the new models file, can also send to Paul D., in advance to test
 +
*Disease OA annotations now converted to the newly created genotypes where needed
 +
*Need to work on disease dumper changes next
  
[[WormBase-Caltech_Weekly_Calls_July_2019|July]]
+
=== What genes should be linked to genotypes? ===
 +
* We have a "Gene" tag in the ?Genotype model for capturing relevant genes
 +
* What should we consider a "relevant gene"?
 +
* We plan to populate the "Gene" tag with genes identified by the variation-to-gene mapping pipeline
 +
* For transgenes, what genes should be extracted as "relevant"? Genes whose promoters are cloned? Genes that are expressed? Genes whose 3'UTR's are cloned? Wild type rescue genes used as a marker/selection tool, e.g. "unc-119(+)"?
 +
* For rearrangements, consider relevant any genes "inside" the rearrangement?
 +
* For now, we will omit any genes from transgenes or rearrangements from being dumped into the "Gene" tag
 +
* In the future, we may want to consider genes that have been specifically annotated as having some functional consequence and informs that the gene is of functional relevance to the genotype
  
[[WormBase-Caltech_Weekly_Calls_August_2019|August]]
+
=== Volunteer Community Curators ===
 +
* Have had an additional 13 people volunteer
 +
* Single one-on-one tutorial for someone in Hong Kong this past Monday
 +
* Chris will hold a tutorial today and tomorrow for everyone else
 +
* Have received many new community annotations from volunteers (and authors), validation still pending
  
[[WormBase-Caltech_Weekly_Calls_September_2019|September]]
+
=== Open Publishing Festival ===
 +
* Ranjana will join as a panelist
 +
* Other MOD curators will also join
 +
* Festival calendar: https://openpublishingfest.org/calendar.html
  
[[WormBase-Caltech_Weekly_Calls_October_2019|October]]
+
=== Move to Chen building ===
 +
* Scheduled for late January 2021
  
[[WormBase-Caltech_Weekly_Calls_November_2019|November]]
+
=== First completely virtual GO meeting ===
 +
* Kimberly: went really well
 +
* Only met 4 hours per day, due to time zone differences
 +
* Had breakout sessions for focus groups
  
[[WormBase-Caltech_Weekly_Calls_December_2019|December]]
+
=== Alliance Literature Acquisition working group ===
 +
* Plan to come up with use cases for OntoMate and Textpresso
 +
**Ontomate link https://rgd.mcw.edu/QueryBuilder/
  
 +
* Kimberly plans to draw up most common use cases for Textpresso
 +
* Google doc for test cases: https://rgd.mcw.edu/QueryBuilder/getResult/?qFieldConditions%5B0%5D.fieldName=ontology&qFieldConditions%5B0%5D.fieldValue=Coronavirus%20infectious%20disease
  
== December 5, 2019 ==
 
  
=== New interaction Venn diagram tool ===
+
== May 21, 2020 ==
* [https://staging.wormbase.org/species/c_elegans/gene/WBGene00000912#08--10 daf-16 interactions]
 
* Venn diagram shows how various interactors have multiple interaction types with a common focus gene
 
* For a given selected gene set, you can copy to clipboard, download CSV, TSV, and link to enrichment analysis or WormMine
 
* Very nice! It would be great to have the gene list options here available wherever lists are provided in WormBase (Sibyl working on it)
 
* Request: add SimpleMine as another link out (go to SimpleMine with the gene list prepopulated)
 
* Request: could there be a toggle to include/exclude high-throughput interactions?
 
* Request: The Venn circle labels sometimes get in the way of seeing the diagram; can they be moved to the side or possibly replace simply with single letters like "P", "G" and "R" for "physical", "genetic" and "regulatory" respectively? Might still need a legend?
 
* Request: Change the wording "Browse selection" to something like "View/analyze gene list"
 
* Where else could we implement a similar type of Venn diagram tool? Disease or phenotype annotations?
 
  
=== New round of phenotype requests ===
+
=== Volunteer curators ===
* GMail really throttling email sending
+
* Received surge of annotations earlier this week
* Chris will reach out to Google/GMail to see if we can:
+
* All tutorials done for now; all but 3 recorded
** A) get a clear explanation about what their restrictions are and how they work and
+
* Each tutorial is ~1 hour in length
** B) see if we can get a paid plan to help expedite the email process (see how much cost)
 
  
=== Aligning interaction data with GO and GO-CAM ===
+
=== AFP tutorial ===
* The Alliance interactions working group is considering proposing a greater alignment between GO interaction annotations (like "binding" annotations with IPI evidence codes, for example) and Alliance molecular interaction annotations
+
* AFP group working on tutorial/webinar
* Also, would like to propose a pipeline for possibly automatically generating GO-CAM annotations/networks based on inferences made from phenotype annotations, genetic interactions, regulatory interactions, and molecular interactions
+
* Had someone on phenotype curation tutorial specifically asking about it (Kimberly responded)
* Much of this depends on genetic perturbation (e.g. allele/variant) annotation to effects, like loss-of-function or gain-of-function annotations
 
** Would be good to get a sense from other Alliance members the extent to which we could rely on the presence of such annotations
 
* Chris and Kimberly will meet to discuss further
 
  
=== Short SObA talk at Alliance meeting ===
+
=== Open Publishing Festival ===
* Raymond prepared to give short talk on SObA to the Alliance group
+
* Had micropublication session yesterday, went well
 +
* Had ~50 participants
 +
* Saved Zoom chats? Can get public ones, maybe not private ones
  
=== Single cell data visualization tool ===
 
* Eduardo will present to Paul's lab meeting tomorrow
 
* Will discuss at Alliance expression working group pre-meeting
 
  
 +
== May 28, 2020 ==
  
== December 19, 2019 ==
+
=== Wormicloud ===
 +
* Introducing a new tool for a graphical summary of queried papers, Please take a look and leave any comments on it. (http://textpressocentral.org:5010/)
  
=== AGR Face to Face meeting debrief ===
+
=== Genes to Physical Map ===
* AGR data need to synchronize with MODs. AGR will have more frequent releases (monthly or every two months) so that it reflects the same data as MODs.
+
* https://colab.research.google.com/drive/1e83jv94-eO_VQ7kKdJ36TgDDb4WRkFhM?usp=sharing
* MODs have different curation policies. For example, BioGrid has predicted protein-protein interactions. AGR import them but WormBase does not have them. AGR needs to do its own prediction based on the current data, although BioGrid does a good job.
+
To run: Runtime->Run All. Change the list of gene names and run again.
* The gene description curation tool developed by Juancarlos got good feedback. Juancarlos will add more function to visualize and compare annotations.
 
* The gene description working group will enter maintenance mode.
 
* Allele phenotype WG will start to the AGR allele page.
 
* SimpleMine vs intermine: Wen argues that there is no conflict. It is like 7-Eleven vs. Walmart (and Biomart is like Target ...)
 
* High-throughput expression: Most of MODs have zero curation manpower thus they prefer to outsource to Express Atlas or GEO unless future grants prioritize curation on high-throughput. Expression Atlas regard worm as a low priority so they may not do much for the worm.
 
* Software development: focus on AGR instead of MODs. SAB hopes all MODs to retire their features to turn more users to AGR.
 
* WormBase should direct all links of orthologs to AGR. Currently, orthologs are pointed to a WormBase page with no content. Wen will create a github ticket for the web team to make the changes.
 
* Paper triage working group: It will be good if MODs can share their paper sources. Karen, Michael Mueller, and Kimberly will be involved in this WG.
 
* Working Groups need more cross-talks, for example, GO and gene description are related.
 
* SoBA got positive feedback. Some groups want to use it to compare two-gene curations, as well as the enrichment analysis.
 
* Non-coding RNA: Paul Sternberg will contact Frank Slack to see what they need for curation.
 

Revision as of 18:15, 28 May 2020

Previous Years

2009 Meetings

2011 Meetings

2012 Meetings

2013 Meetings

2014 Meetings

2015 Meetings

2016 Meetings

2017 Meetings

2018 Meetings

2019 Meetings


GoToMeeting link: https://www.gotomeet.me/wormbase1

2020 Meetings

January

February

March

April


May 7, 2020

Alliance COVID Page

  • Available on stage
  • Textpresso for Coronavirus up for testing

SimpleMine at Alliance

  • Still some confusion about what it is
  • Will try to help clarify on PI meeting on Friday

Development environment for Alliance work

  • Raymond and Juancarlos have been working on
  • Existing hardware is strained; set up virtual machine
  • Still some technical issues

Open Publishing Festival

  • Later this month
  • Micropublications involved
  • Organized by the Collaborative Knowledge Foundation
  • Will involve publishers of books, journals, etc.
  • Will have a MOD-focused event, would be good to have WB curators participate/attend
  • Open to all

Genotype class

  • Ranjana finished populating the Genotype OA with genotypes needed for disease curation
  • Will need to keep in mind that we will have a mapping pipeline to determine which genes are involved for a variation
  • There could end up being a discrepancy between an original or published name of a genotype and the components that are inferred by WormBase
  • Would be good to be clear/transparent about which components were automatically inferred

WS277/278

  • Pipelines are pushed back by about 14 days/2 weeks


May 13, 2020

SURF students

  • Welcome Fernando!
  • Will work on neuron function with respect to dauer formation

Progress Report

Genotype class

  • Have 27 genotypes in the genotype OA, dumper and test .ace file ready
  • Will test ace file in citace as soon as we get the new models file, can also send to Paul D., in advance to test
  • Disease OA annotations now converted to the newly created genotypes where needed
  • Need to work on disease dumper changes next

What genes should be linked to genotypes?

  • We have a "Gene" tag in the ?Genotype model for capturing relevant genes
  • What should we consider a "relevant gene"?
  • We plan to populate the "Gene" tag with genes identified by the variation-to-gene mapping pipeline
  • For transgenes, what genes should be extracted as "relevant"? Genes whose promoters are cloned? Genes that are expressed? Genes whose 3'UTR's are cloned? Wild type rescue genes used as a marker/selection tool, e.g. "unc-119(+)"?
  • For rearrangements, consider relevant any genes "inside" the rearrangement?
  • For now, we will omit any genes from transgenes or rearrangements from being dumped into the "Gene" tag
  • In the future, we may want to consider genes that have been specifically annotated as having some functional consequence and informs that the gene is of functional relevance to the genotype

Volunteer Community Curators

  • Have had an additional 13 people volunteer
  • Single one-on-one tutorial for someone in Hong Kong this past Monday
  • Chris will hold a tutorial today and tomorrow for everyone else
  • Have received many new community annotations from volunteers (and authors), validation still pending

Open Publishing Festival

Move to Chen building

  • Scheduled for late January 2021

First completely virtual GO meeting

  • Kimberly: went really well
  • Only met 4 hours per day, due to time zone differences
  • Had breakout sessions for focus groups

Alliance Literature Acquisition working group


May 21, 2020

Volunteer curators

  • Received surge of annotations earlier this week
  • All tutorials done for now; all but 3 recorded
  • Each tutorial is ~1 hour in length

AFP tutorial

  • AFP group working on tutorial/webinar
  • Had someone on phenotype curation tutorial specifically asking about it (Kimberly responded)

Open Publishing Festival

  • Had micropublication session yesterday, went well
  • Had ~50 participants
  • Saved Zoom chats? Can get public ones, maybe not private ones


May 28, 2020

Wormicloud

Genes to Physical Map

To run: Runtime->Run All. Change the list of gene names and run again.