Difference between revisions of "WormBase-Caltech Weekly Calls"

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[[WormBase-Caltech_Weekly_Calls_2018|2018 Meetings]]
 
[[WormBase-Caltech_Weekly_Calls_2018|2018 Meetings]]
 +
 +
[[WormBase-Caltech_Weekly_Calls_2019|2019 Meetings]]
  
  
 
GoToMeeting link: https://www.gotomeet.me/wormbase1
 
GoToMeeting link: https://www.gotomeet.me/wormbase1
  
 +
= 2020 Meetings =
  
= 2019 Meetings =
+
== January 9, 2020 ==
 
 
[[WormBase-Caltech_Weekly_Calls_January_2019|January]]
 
 
 
[[WormBase-Caltech_Weekly_Calls_February_2019|February]]
 
 
 
[[WormBase-Caltech_Weekly_Calls_March_2019|March]]
 
 
 
[[WormBase-Caltech_Weekly_Calls_April_2019|April]]
 
 
 
[[WormBase-Caltech_Weekly_Calls_May_2019|May]]
 
 
 
[[WormBase-Caltech_Weekly_Calls_June_2019|June]]
 
 
 
[[WormBase-Caltech_Weekly_Calls_July_2019|July]]
 
 
 
[[WormBase-Caltech_Weekly_Calls_August_2019|August]]
 
 
 
[[WormBase-Caltech_Weekly_Calls_September_2019|September]]
 
 
 
[[WormBase-Caltech_Weekly_Calls_October_2019|October]]
 
  
[[WormBase-Caltech_Weekly_Calls_November_2019|November]]
+
=== Phenotype Curation Requests ===
 +
* 1,229 emails sent Dec 3-6, 2019
 +
* Received 194 annotations from 40 papers and from 37 distinct community curators
 +
** 37 papers requested, 3 additional papers annotated
 +
** 104 Phenotype OA annotations (from 27 papers; 25 distinct curators)
 +
** 90 RNAi OA annotations (from 20 papers; 19 distinct curators)
 +
* 43 bounced emails
 +
** 2 resent to new addresses
 +
** 5 have backup email addresses (also sent)
  
[[WormBase-Caltech_Weekly_Calls_December_2019|December]]
+
=== Worm Area Meetings ===
 +
* Chris has (re)requested slots for WormBase for the Worcester Area Worm Meeting and the Boston Area Worm Meeting
 +
* Will update group if/when a slot is assigned (probably not until Fall 2020 at the earliest)
  
 +
=== Reference widget Textpresso linkouts ===
 +
* Now live on WormBase, WS274
 +
* [https://github.com/WormBase/website/issues/7347 GitHub ticket]
 +
* Applies to the following classes: genes, strains, variations, transgenes, constructs, anatomy terms, clones, life stages, rearrangements, molecules, processes
 +
* Gene example: https://wormbase.org/species/c_elegans/gene/WBGene00022861#0d--10
 +
* Strain example: https://wormbase.org/species/c_elegans/strain/WBStrain00004309#05--10
 +
* Variation example: https://wormbase.org/species/c_elegans/variation/WBVar00248884#08--10
 +
* Transgene example: https://wormbase.org/species/all/transgene/WBTransgene00004654#04--10
 +
** Known issue: searching on synonyms in addition to public name; Sibyl will fix
 +
* Construct example: https://wormbase.org/species/all/construct/WBCnstr00023113#03--10
 +
** Known issue: not working now; need to only search on public name when available, not on summary; Sibyl will fix
 +
* Anatomy term example: https://wormbase.org/species/all/anatomy_term/WBbt:0005772#05--10
 +
** Known challenge: "Psub1" will essentially never match the intended target and "P1" may find the embryonic cell or the postembryonic cell
 +
* Clone example: https://wormbase.org/species/c_elegans/clone/W02C12#03--10
 +
* Life stage example: https://wormbase.org/species/all/life_stage/WBls:0000038#03--10
 +
** Known challenge: "L4 larva Ce" will never match; "L4 larva" maybe; but "L4" alone will not unless a synonym
 +
* Rearrangement example: https://wormbase.org/species/all/rearrangement/sDp3#03--10
 +
* Molecule example: https://wormbase.org/resources/molecule/WBMol:00003650#03--10
 +
* Process examples:
 +
** https://wormbase.org/resources/wbprocess/WBbiopr:00000001#09--10
 +
** https://wormbase.org/resources/wbprocess/WBbiopr:00000079#09--10
 +
* Michael has improved phrase search and combined supplemental documents with main paper documents; should roll out soon
  
== December 5, 2019 ==
+
=== WS276 Citace upload ===
 +
* Hinxton upload Jan 31, 2020
 +
* Citace upload on Tuesday, Jan 28, 2020
  
=== New interaction Venn diagram tool ===
+
=== Author First Pass paper ===
* [https://staging.wormbase.org/species/c_elegans/gene/WBGene00000912#08--10 daf-16 interactions]
+
* AFP resent to Database
* Venn diagram shows how various interactors have multiple interaction types with a common focus gene
+
* Automated descriptions about to be sent
* For a given selected gene set, you can copy to clipboard, download CSV, TSV, and link to enrichment analysis or WormMine
+
* SObA, write for micropub? One micropub on SObA and another on comparative SObA
* Very nice! It would be great to have the gene list options here available wherever lists are provided in WormBase (Sibyl working on it)
 
* Request: add SimpleMine as another link out (go to SimpleMine with the gene list prepopulated)
 
* Request: could there be a toggle to include/exclude high-throughput interactions?
 
* Request: The Venn circle labels sometimes get in the way of seeing the diagram; can they be moved to the side or possibly replace simply with single letters like "P", "G" and "R" for "physical", "genetic" and "regulatory" respectively? Might still need a legend?
 
* Request: Change the wording "Browse selection" to something like "View/analyze gene list"
 
* Where else could we implement a similar type of Venn diagram tool? Disease or phenotype annotations?
 
  
=== New round of phenotype requests ===
+
=== Noctua/GO-CAM ===
* GMail really throttling email sending
+
* New version of the Noctua form released next week
* Chris will reach out to Google/GMail to see if we can:
+
* Imports from WormBase?
** A) get a clear explanation about what their restrictions are and how they work and
+
** Big push in coming months will be to pull in all manual annotations from WB into Noctua (on track)
** B) see if we can get a paid plan to help expedite the email process (see how much cost)
+
** Need to work on annotation history on back end
 +
** May have face-to-face meeting in Pasadena
  
=== Aligning interaction data with GO and GO-CAM ===
+
=== Variation curation ===
* The Alliance interactions working group is considering proposing a greater alignment between GO interaction annotations (like "binding" annotations with IPI evidence codes, for example) and Alliance molecular interaction annotations
+
* Have a backlog; Paul D is assigned but has been overwhelmed
* Also, would like to propose a pipeline for possibly automatically generating GO-CAM annotations/networks based on inferences made from phenotype annotations, genetic interactions, regulatory interactions, and molecular interactions
+
* Have asserted this as a priority
* Much of this depends on genetic perturbation (e.g. allele/variant) annotation to effects, like loss-of-function or gain-of-function annotations
+
* We have the allele-sequence form; where does it go? Hinxton
** Would be good to get a sense from other Alliance members the extent to which we could rely on the presence of such annotations
+
* Need to get allele/variation data in an Alliance-submission friendly form and pull it into the Alliance
* Chris and Kimberly will meet to discuss further
+
* Need to integrate curation with the Variant Effect Predictor (VEP) pipeline
  
=== Short SObA talk at Alliance meeting ===
+
=== Topic meetings ===
* Raymond prepared to give short talk on SObA to the Alliance group
+
* Asia (Taipei) meeting, Paul S going
 +
* Aging meeting, Wen could go? (Wen: I can ask if they provide a timeslot for oral presentation.)
 +
* TAGC in April, Chris going
  
=== Single cell data visualization tool ===
 
* Eduardo will present to Paul's lab meeting tomorrow
 
* Will discuss at Alliance expression working group pre-meeting
 
  
 +
== January 16, 2020 ==
  
== December 19, 2019 ==
+
=== Variation names ===
 +
* Daniela entered a new allele name (tkTi1) in the temporary allele form CGI but it prompted an error: tkTi1 does not match 1 or 2 sets of 1-3 letters and 1-6 digits
.
 +
* Daniela asked Juancarlos to modify the temporary variation ID form to allow up to 4 letters instead of 3.
 +
* Form here: http://tazendra.caltech.edu/~azurebrd/cgi-bin/forms/generic.cgi?action=TempVariationObo
 +
* From the nomenclature guidelines: Newly generated Transposon insertions, especially those located in apparently intergenic regions, may also be given Ti (transposon insertion) names. These consist of the designation identifying the laboratory of origin, the two letters Ti, and a number, all italicized. Example: eTi13 is an insertion of a Mos transposon into an intergenic region on LGIII.
 +
* We will wait for Paul D/Tim response and act accordingly
 +
* for now the CGI has been changed to allow 4 letters, we will revert if need be
  
=== AGR Face to Face meeting debrief ===
+
=== Webinars ===
* AGR data need to synchronize with MODs. AGR will have more frequent releases (monthly or every two months) so that it reflects the same data as MODs.
+
* During an AFP call we discussed the possibility to have webinars for authors to guide them through the form.
* MODs have different curation policies. For example, BioGrid has predicted protein-protein interactions. AGR import them but WormBase does not have them. AGR needs to do its own prediction based on the current data, although BioGrid does a good job.
+
* Is having a webinar series something WB is interested in doing?
* The gene description curation tool developed by Juancarlos got good feedback. Juancarlos will add more function to visualize and compare annotations.
+
** we will start with an AFP/micropub webinar and will take it from there based on interest and attendance
* The gene description working group will enter maintenance mode.
 
* Allele phenotype WG will start to the AGR allele page.
 
* SimpleMine vs intermine: Wen argues that there is no conflict. It is like 7-Eleven vs. Walmart (and Biomart is like Target ...)
 
* High-throughput expression: Most of MODs have zero curation manpower thus they prefer to outsource to Express Atlas or GEO unless future grants prioritize curation on high-throughput. Expression Atlas regard worm as a low priority so they may not do much for the worm.
 
* Software development: focus on AGR instead of MODs. SAB hopes all MODs to retire their features to turn more users to AGR.
 
* WormBase should direct all links of orthologs to AGR. Currently, orthologs are pointed to a WormBase page with no content. Wen will create a github ticket for the web team to make the changes.
 
* Paper triage working group: It will be good if MODs can share their paper sources. Karen, Michael Mueller, and Kimberly will be involved in this WG.
 
* Working Groups need more cross-talks, for example, GO and gene description are related.
 
* SoBA got positive feedback. Some groups want to use it to compare two-gene curations, as well as the enrichment analysis.
 
* Non-coding RNA: Paul Sternberg will contact Frank Slack to see what they need for curation.
 

Revision as of 20:05, 16 January 2020

Previous Years

2009 Meetings

2011 Meetings

2012 Meetings

2013 Meetings

2014 Meetings

2015 Meetings

2016 Meetings

2017 Meetings

2018 Meetings

2019 Meetings


GoToMeeting link: https://www.gotomeet.me/wormbase1

2020 Meetings

January 9, 2020

Phenotype Curation Requests

  • 1,229 emails sent Dec 3-6, 2019
  • Received 194 annotations from 40 papers and from 37 distinct community curators
    • 37 papers requested, 3 additional papers annotated
    • 104 Phenotype OA annotations (from 27 papers; 25 distinct curators)
    • 90 RNAi OA annotations (from 20 papers; 19 distinct curators)
  • 43 bounced emails
    • 2 resent to new addresses
    • 5 have backup email addresses (also sent)

Worm Area Meetings

  • Chris has (re)requested slots for WormBase for the Worcester Area Worm Meeting and the Boston Area Worm Meeting
  • Will update group if/when a slot is assigned (probably not until Fall 2020 at the earliest)

Reference widget Textpresso linkouts

WS276 Citace upload

  • Hinxton upload Jan 31, 2020
  • Citace upload on Tuesday, Jan 28, 2020

Author First Pass paper

  • AFP resent to Database
  • Automated descriptions about to be sent
  • SObA, write for micropub? One micropub on SObA and another on comparative SObA

Noctua/GO-CAM

  • New version of the Noctua form released next week
  • Imports from WormBase?
    • Big push in coming months will be to pull in all manual annotations from WB into Noctua (on track)
    • Need to work on annotation history on back end
    • May have face-to-face meeting in Pasadena

Variation curation

  • Have a backlog; Paul D is assigned but has been overwhelmed
  • Have asserted this as a priority
  • We have the allele-sequence form; where does it go? Hinxton
  • Need to get allele/variation data in an Alliance-submission friendly form and pull it into the Alliance
  • Need to integrate curation with the Variant Effect Predictor (VEP) pipeline

Topic meetings

  • Asia (Taipei) meeting, Paul S going
  • Aging meeting, Wen could go? (Wen: I can ask if they provide a timeslot for oral presentation.)
  • TAGC in April, Chris going


January 16, 2020

Variation names

  • Daniela entered a new allele name (tkTi1) in the temporary allele form CGI but it prompted an error: tkTi1 does not match 1 or 2 sets of 1-3 letters and 1-6 digits
.
  • Daniela asked Juancarlos to modify the temporary variation ID form to allow up to 4 letters instead of 3.
  • Form here: http://tazendra.caltech.edu/~azurebrd/cgi-bin/forms/generic.cgi?action=TempVariationObo
  • From the nomenclature guidelines: Newly generated Transposon insertions, especially those located in apparently intergenic regions, may also be given Ti (transposon insertion) names. These consist of the designation identifying the laboratory of origin, the two letters Ti, and a number, all italicized. Example: eTi13 is an insertion of a Mos transposon into an intergenic region on LGIII.
  • We will wait for Paul D/Tim response and act accordingly
  • for now the CGI has been changed to allow 4 letters, we will revert if need be

Webinars

  • During an AFP call we discussed the possibility to have webinars for authors to guide them through the form.
  • Is having a webinar series something WB is interested in doing?
    • we will start with an AFP/micropub webinar and will take it from there based on interest and attendance