Difference between revisions of "WormBase-Caltech Weekly Calls"
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** "ineffective" | ** "ineffective" | ||
** "perturbation that disrupts" | ** "perturbation that disrupts" | ||
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** Failure to execute the characteristic response = abnormal? | ** Failure to execute the characteristic response = abnormal? | ||
** abnormal | ** abnormal |
Revision as of 18:15, 12 September 2019
Contents
Previous Years
GoToMeeting link: https://www.gotomeet.me/wormbase1
2019 Meetings
September 12, 2019
Update on SVM pipeline
- New SVM pipeline: more analysis and more parameter tuning
- avoiding precision (and F-value) as a measure (dependent on ratio of positives and negatives in test set)
- "dumb" machine starts out with precision above 0.6
- G-value (Michael's invention); does not depend on distribution of sets
- Applied to various data types
- Analysis: 10-fold cross validation
- Randomly select 10% pos and neg (without replacement) and repeat until all papers sampled
- F-value changes over different p/n values; G-value does not (essentially flat)
- Area Under the Curve (AUC): probability that a random positive scores higher than random negative
- AUC values for many WB data types upper 80%'s into 90%'s
- Ranjana: How many papers for a good training set? Michael: we don't know yet
- Can't reproduce old training sets (for old SVM); provide Michael better training sets if you want improved SVM
- If SVM still not good enough, Michael will work on deep neural networks (Tensor Flow)
- Michael can provide training sets he has used recently
Clarifying definitions of "defective" and "deficient" for phenotypes
- WB phenotype ontology has many "variant/abnormal" terms and distinct subclass terms for "defective/deficient"
- Have tried to create a logical definition pattern for these terms, but the vagueness of the meaning of "defective" and how it is distinct from "abnormal" has stalled the process
- What do we mean exactly by "defective" and how, specifically, is this distinct from "abnormal"?
- Definitions include meanings or words:
- "Variations in the ability"
- "aberrant"
- "defect"
- "defective"
- "defects"
- "deficiency"
- "deficient"
- "disrupted"
- "impaired"
- "incompetent"
- "ineffective"
- "perturbation that disrupts"
- Failure to execute the characteristic response = abnormal?
- abnormal
- abnormality leading to specific outcomes
- fail to exhibit the same taxis behavior = abnormal?
- failure
- failure OR delayed
- failure, slower OR late
- failure/abnormal
- reduced
- slower