WBPaper00038523 GO linking comments

back

WBPaper00038523

doi10.1534/genetics.111.130450 00038523
GO_linked_html
GO_entity_list

Comments concerning GO linking of this paper

karen

• authors discuss many types of 'aging', which are all linking to one GO term "aging"- the authors are setting out to distinguish aging events that occur in different tissues, so the global linking of all instances of 'aging' throughout this paper is counter to the point the author is trying to make.

• non-informative links -- in most of these cases, it would be good if there were GO terms that actually could capture the whole phrase
  • regulation
  • aging when referring to 'reproductive aging', 'somatic aging', 'human aging', 'C. elegans aging'
  • kinase as part of phosphatidylinositol-3-kinase
  • reproduction as part of 'late reproduction', 'early reproduction'
  • insulin-like growth factor in 'insulin-like growth factor-1'
  • growth in 'nematode growth media'
  • development in 'dauer development'
  • receptor and kinase in 'receptor tyrosine kinase'
  • fertilization in 'self-fertilization'
  • formation in 'dauer formation'
  • mating is not an informative link here, the GO definition is too cellular-based to capture the essence of how mating is used here.
  • signaling pathway is not as informative as a link to 'insulin/IGF-1 signaling pathway'
  • gametogenesis seems like a good link but the use of gametophyte in the GO definition is non-animals centered
  • cell in 'germ cell'
  • ovulation -the GO term definition does not seem broad enough
  • reflex this does not match the meaning of the GO term