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| = Agenda = | | = Agenda = |
− | == ParaSite Prototype ==
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− | == nurf-1 Gene structure ==
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− | In C. elegans, nurf-1 is a complex gene structure that is composed of two main regions.
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− | Many isoforms are apparent in this locus. Some of these terminate halfway through the locus, some start in the second half and some span both halves.
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− | In C. briggsae, C. japonica and C. remanei the homologous region to Cel-nurf-1 is composed of two completely separate genes, according to our normal gene curation standards.
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− | In Drosophila and Human, the homologous region is a single complex gene producing many different isoforms, some of which span the two halves, as in C. elegans.
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− | We have a user who is requesting help in naming this locus in C. briggsae for a paper.
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− | There are other examples of complex gene loci that have a variety of CGC names.
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− | Often our hand has been forced as authors have imposed their view of how these should be named before a discussion of the implications.
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− | This has resulted in loci where we have the annotation as:
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− | - A single gene locus - single CGC name and single WBGene ID with non-overlapping isoforms.
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− | - A completely different gene products - two CGC names and two WBGene IDs
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− | We are aware that having a single CGC name shared between two different genes could result in problems for the website.
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− | How should we represent and name these sort of loci in the future?
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