UniProt Paper - Gene - Data Type

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Original file generated for UniProt:

http://tazendra.caltech.edu/~azurebrd/cgi-bin/forms/uniprot.cgi

Updates to file will now include data types curated for a given gene.


What we currently supply:

WBGene WBPaperID PMID

Not sure how this is generated - before my time.


What we need to add:

WBGene WBPaperID PMID Category


The Categories would be gene-specific and we will supply information for:

GO:PPI;Phenotype;Disease;Expression;Sequence

An example:

    WBGene00003508  WBPaper



Strategy: Several possible strategies - not sure which is best.

Easiest to get everything from WS or a mixture of WS and postgres?

Some things, like GO, RNAi and Variation Phenotypes, need to be from WS

1) Start with Paper object and then trace the data types in the Refers_to tag - this works for everything but Disease

2) Look at each object in each relevant class - this seems computationally very intensive


How to map this onto our data types from each WS release:


GO:

    ?GO_annotation -> Gene
                   -> Reference


PPI:

    ?Interaction -> Interaction_type Physical
                 -> Interactor_overlapping_gene
                 -> Paper


Phenotype:

    ?RNAi -> Inhibits
          -> Phenotype
          -> Reference
    ?Variation -> Affects
                -> Phenotype
                -> Reference


Expression:

    ?Expr_pattern -> Expression_of -> Gene
                  -> Reference


Sequence:

    ?Variation -> Affects
               -> Nonsense
               -> Missense
               -> Silent			Any one of these filled in
               -> Splice_site
               -> Frameshift
               -> Readthrough
               -> Reference

Disease:

    ?Gene -> Disease_info -> Experimental -> Evidence -> Paper_evidence
          -> Disease_info -> Disease_relevance -> Evidence -> Paper_evidence