Relations Ontology

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  • The Relations Ontology is used in WormBase to describe relations between entities in the database, e.g. genes and GO terms.
  • The Relations Ontology was first incorporated into WormBase with the WS267 release.

?RO_term Model

 ?RO_term Name UNIQUE ?Text
          Status UNIQUE Valid
          Alt_id ?Text
          Definition UNIQUE ?Text
          Synonym Broad ?Text
                  Exact ?Text
                  Narrow ?Text
                  Related ?Text
          Child Instance ?RO_term XREF Instance_of
          Parent Instance_of ?RO_term XREF Instance
          Attribute_of GO_annotation ?GO_annotation XREF Annotation_relation
                       Not_GO_annotation ?GO_annotation XREF Annotation_relation_not 
          Index Ancestor ?RO_term XREF Descendant
                Descendant ?RO_term XREF Ancestor
          Version UNIQUE Text

Parsing Script for ?RO_term Model

  • The parsing script to generate the ro_terms.ace file is on tazendra here:
    • /home/acedb/kimberly/citace_upload/ro/ontology2ace/
  • Output file:
    • ro_terms.ace
  • There are two types of entries in ro.obo
    • Term
    • Typedef
  • At the moment, we include Term and Typedef entries according to the following criteria:
    • Include term where id namespace = BFO, RO, lower case text with no namespace: (e.g. results_in_acquisition_of_features_of)
    • Skip term where id namespace = CARO, CL, ENVO, GO, ObsoleteClass, PATO
  • Note that the terms we skip are used in the OWL representation of the Relations Ontology, but not in the OBO representation
    • For the purposes of how the Relations Ontology will initially be used in WormBase, this filtering step should be fine
  • Running the script:
  1. In the /home/acedb/kimberly/citace_upload/ro/ontology2ace directory on tazendra, use the wget command to download the ro.obo input file

Update spelling to Descendant in ?GO_term model

  • Update line 89 in (change e -> a)

go_gpad_parser modifications


Line 130 - Will instead need a mapping between annotation relation and RO term id

When just relation -> Annotation_relation

When NOT|relation -> Annotation_relation_not

This may be temporary as it was proposed at the NYC GO meeting to start using RO ids in place of text in the qualifier/relation column of at least the GPAD file

Eventually this should also be the case for the Annotation extension relations, but there are some used in AEs that are not in RO

Mappings (as of June 12th):

  • colocalizes_with RO:0002325 110
  • contributes_to RO:0002326 277
  • enables RO:0002327 22903
  • involved_in RO:0002331 32498
  • part_of BFO:0000050 33772

NOT annotations 224

go_oa_parser modifications


Line 56 - relations are stored in the gop_qualifier table

Will need to output the same as above

Mappings (as of June 12th):

  • colocalizes_with RO:0002325 0
  • contributes_to RO:0002326 0
  • enables RO:0002327 20
  • involved_in RO:0002331 334
  • part_of BFO:0000050 29

NOT annotations 0