Difference between revisions of "Relations Ontology"

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Line 19: Line 19:
 
                         Not_GO_annotation ?GO_annotation XREF Annotation_relation_not  
 
                         Not_GO_annotation ?GO_annotation XREF Annotation_relation_not  
 
           Index Ancestor ?RO_term XREF Descendant
 
           Index Ancestor ?RO_term XREF Descendant
                    Descendant ?RO_term XREF Ancestor
+
                  Descendant ?RO_term XREF Ancestor
 
           Version UNIQUE Text
 
           Version UNIQUE Text
  

Revision as of 15:39, 29 June 2018

Overview

  • The Relations Ontology is used in WormBase to describe relations between entities in the database, e.g. genes and GO terms.
  • The Relations Ontology was first incorporated into WormBase with the WS267 release that included the ?RO_term model.

?RO_term Model

  • ?RO_term proposal sent to models@wormbase list
 ?RO_term Name UNIQUE ?Text
          Status UNIQUE Valid
                        Obsolete
          Alt_id ?Text
          Definition UNIQUE ?Text
          Synonym Broad ?Text
                  Exact ?Text
                  Narrow ?Text
                  Related ?Text
          Child Instance ?RO_term XREF Instance_of
          Parent Instance_of ?RO_term XREF Instance
          Attribute_of GO_annotation ?GO_annotation XREF Annotation_relation
                       Not_GO_annotation ?GO_annotation XREF Annotation_relation_not 
          Index Ancestor ?RO_term XREF Descendant
                 Descendant ?RO_term XREF Ancestor
          Version UNIQUE Text

Parsing Scripts for ?RO_term Model

?RO_term class

.ace parsing script for ?GO_term that can serve as a template (See /home/acedb/kimberly/citace_upload/go/ontology2ace/go_obo2ace/go_obo_to_go_ace.pl)

Output file: RO_terms.ace

RO obo file location for download: https://raw.githubusercontent.com/oborel/obo-relations/master/ro.obo

Right now, we will parse the obo file; the day may come, though, when we will want/need to parse the owl file.

Terms to Include: Include term where id namespace = BFO, RO, lower case text with no namespace: (e.g. results_in_acquisition_of_features_of)

Skip term where id namespace = CARO, CL, ENVO, GO, ObsoleteClass, PATO

Skip where is_obsolete: true

Fields to include, mapped to ?RO_term model tag (note that we can re-use much of the ?GO_term parsing script):

  • Id: -> RO_term
  • Name: -> Name
  • Status -> Valid
  • alt_id: -> Alt_id
  • Def: -> Definition (parse what is in quotes)
  • Synonym: -> Synonym (parse what is in caps to match Type and then the text that is in quotes
  • Data-version: -> Version

Review GO term parser for handling is_a relationships to populate Child, Parent, Index

Parsing report/sanity check: What terms have no ancestors? What terms have no descendants?

Update spelling to Descendant in ?GO_term model

  • Update line 89 in (change e -> a)

go_gpad_parser modifications

/home/acedb/kimberly/citace_upload/go/gpad2ace/2018_June_test/go_gpad_parser.pl

Line 130 - Will instead need a mapping between annotation relation and RO term id

When just relation -> Annotation_relation

When NOT|relation -> Annotation_relation_not

This may be temporary as it was proposed at the NYC GO meeting to start using RO ids in place of text in the qualifier/relation column of at least the GPAD file

Eventually this should also be the case for the Annotation extension relations, but there are some used in AEs that are not in RO

Mappings (as of June 12th):

  • colocalizes_with RO:0002325 110
  • contributes_to RO:0002326 277
  • enables RO:0002327 22903
  • involved_in RO:0002331 32498
  • part_of BFO:0000050 33772

NOT annotations 224

go_oa_parser modifications

/home/postgres/work/citace_upload/go_curation/get_go_annotation_ace.pm

Line 56 - relations are stored in the gop_qualifier table

Will need to output the same as above

Mappings (as of June 12th):

  • colocalizes_with RO:0002325 0
  • contributes_to RO:0002326 0
  • enables RO:0002327 20
  • involved_in RO:0002331 334
  • part_of BFO:0000050 29

NOT annotations 0