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Disease

Disease search

  • Disease.ace file generated for addition to Xapian search system
  • File in /usr/local/wormbase/databases/{RELEASE}/orthology and automatically generated by orthology data compile

Michael Paulini's development towards tighter disease incorporation

Responding to MP's notes

  • mark the elegans/worm genes with omim ortholgs, as caltech is unable to query into the proteins (done by me and will be in ws227)
    • file with the associations available from the orthology data compile -- /usr/local/wormbase/databases/{RELEASE}/orthology/go_id2omim_ids.txt
    • details of this file documented in table: [[1]]
  • put the omim descriptions into the database ... and I thought there of you and your flat files to get the data. That would end up in the accession numbers ... end they in turn would need some omim: prefix or so, as else their are just numbers
    • file with details of OMIM diseases available from the orthology data compile -- /usr/local/wormbase/databases/{RELEASE}/orthology/omim_id2disease_desc.txt
    • details of this file documented in table: [[2]]
  • would be nice if the functinality of searching through omim descriptions and showing genes connected to diseases would reappear on the new site, but I don't know how, as acedb might be a bit slowish to search through the text (but maybe it is fast enough).
    • see note re: disease search above, generated file includes requested data
  • the omim database record needs to be updated, as omim is now on www.omim.org (done by Mary Ann and will be in ws227). I don't know of it was one of our best ideas to put the urls into acedb, as it now takes two months to fix broken links.
    • caltech issue
  • caltech needs to update their descriptions based on our omim data (will start asking them after ws227)
    • see above, info available
  • Show phenotypes of connected genes on the disease pages, as they might be handy
    • Can be done; data from the soon-to-be-deprecated CompileGeneResources has all necessary information -- /usr/local/wormbase/databases/{RELEASE}/gene
  • Kev thought of creating a disease class instead of putting it as text into the accession numbers. Especially since we cover plant and animal parasites in addition.
    • Would be great

Model

  • adding PODs
  • see Disease.pm

Orthology

Model

  • Information/Functionality incorporated into Gene Model; providing development support providing development support as WB2 moves forward

UI

  • providing development support as WB2 moves forward

Paralog model additions for gene evolution

  • paralog data being ported from classic site usr/local/wormbase/website/classic/cgi-perl/orthology/gene to Gene.pm

Paralog UI for gene evolution

  • in planning stage

Ontology

Model

  • providing development support as WB2 moves forward

UI

  • providing development support as WB2 moves forward

Tree_lister

  • currently an external resource from dev site re-engineered to work with WB2
  • location: /usr/local/wormbase/website/classic/cgi-perl/ontology/tree_lister

Search

  • should be super-ceded by Xapian system

Position matrix data

Data compile

  • developing module for pipeline
  • Positiion matrix needs alot of work. I'll periodically jump in to fix things to try to get a compile done b/4 WS227
  • necessary code is in /home/norie/dev/position_matrix
  • Steps -- roughly:
  • generates instructions for R to create data files into input directory
    • create_consensus_r_files.pl
    • create_pwm_data_files.pl
    • create_pwm_r_files.pl
  • take instructions from input directory and runs appropriate R processes to generate consensus files
    • generate_consensus.pl
    • generate_sl.pl
    • generate_pm_id2consensus.pl

Documentation

  • ongoing

Miscellaneous UIs