How WormBase writes a concise description
Writing a concise description for a C. elegans gene
Curators as a general rule make sure that the following key facts are captured in a concise description, when this information is available in published literature, please do not use information from meeting abstracts, Worm Breeder Gazette articles, personal observations, etc.:
- Molecular identity
- Genetic interactions
- Physical interactions
- Function/Molecular Activity
- Tissue Expression
- Sub cellular localization
So, the template for a concise description will look something like:
Molecular identity <Gene> encodes .....; Orthology/Similarity <Gene> is <orthologous, similar) to .....; Process/Pathway <Gene> is <required, functions, regulates, is involved in, is part of> .....; Genetic interaction with respect to Process or Pathway <Gene> interacts genetically with <gene1, gene2>..... in <Process, Pathway>; Physical interaction <Protein> physically interacts with <protein, DNA, RNA).......; Molecular Function <Protein> has ……… activity in <in vitro, in vivo> assays; Tissue Expression <Gene/Protein> is expressed in …………and expression in ......is (positively, negatively) regulated by .......; Sub-cellular localization <Protein> is localized to <sub-cellular component> or .......and expression in <sub-cellular component> is <positively, negatively> regulated by ........
Note that the above template is to be used a guide, and not all descriptions may follow the exact order or choice of words. Examples of concise descriptions written by WormBase:
lin-10 lin-10 encodes a PDZ and PTB domain-containing protein that is homologous to mammalian Munc interacting proteins (Mint1) and is required for polarized protein localization; LIN-10 is required for proper localization of the LET-23 EGF receptor to the basolateral membrane of the vulval precursor cells and for proper postsynaptic localization of GLR-1, an AMPA-type glutamate receptor in interneurons; LIN-10 is detected in the cytoplasm, membrane, and at particularly high levels in the Golgi.