How WormBase writes a concise description
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Jump to navigationJump to searchWriting a concise description for a C. elegans gene
The following key facts are captured in a concise description, when this information is available in the published literature. Please do not use information from meeting abstracts, Worm Breeder Gazette articles and personal observations/communications.
- Molecular identity
- Orthology
- Process/Pathway
- Genetic interactions
- Physical interactions
- Function/Molecular Activity
- Tissue Expression
- Sub cellular localization
So, the template for a concise description would look like:
Molecular identity <Gene> encodes .....; Orthology/Similarity <Gene> is <orthologous, similar) to .....; Process/Pathway <Gene> is <required, functions, regulates, is involved in, is part of> .....; Genetic interaction <Gene> interacts genetically with <gene1, gene2> ..... in <Process, Pathway>; Physical interaction <Protein> physically interacts with <protein, DNA, RNA) .....; Molecular Function <Protein> has ..... activity in <in vitro, in vivo> assays; Tissue Expression <Gene/Protein> is expressed in ..... and expression in ..... is (positively, negatively) regulated by .....; Sub-cellular localization <Protein> is localized to <cellular component> and expression in <cellular component> is <positively, negatively> regulated by .....
Note that the above template is to be used as a guide, and not all descriptions may follow the exact order or choice of words.
Examples of concise descriptions written by WormBase:
Example: lin-10
lin-10 encodes a PDZ and PTB domain-containing protein that is homologous to mammalian Munc interacting proteins (Mint1) and is required for polarized protein localization; LIN-10 is required for proper localization of the LET-23 EGF receptor to the basolateral membrane of the vulval precursor cells and for proper postsynaptic localization of GLR-1, an AMPA-type glutamate receptor in interneurons; LIN-10 is detected in the cytoplasm, membrane, and at particularly high levels in the Golgi.
Example: lon-1
The lon-1 gene encodes a protein belonging to the PR-protein superfamily that is a target of DBL-1 (TGF-beta) signaling, and that regulates polyploidization and body length.