To enable curators (disease curators and then maybe phenotype curators) to annotate directly to entire genotypes, the ?Genotype class has been proposed. The decision was made that any ?Genotype object should reflect the entire genotype of a particular worm or strain of worms, to the extent that it is known, rather than partial genotypes. The initial data model allows for direct associations to disease model annotations, whereby genotype associations to diseases (DO terms) would then be made during the Postgres curation database dump.
?Genotype Genotype_name UNIQUE ?Text // e.g. “unc-1(e103);unc-2(e234)” Genotype_component Gene ?Gene XREF Component_of_genotype #Evidence Variation ?Variation XREF Component_of_genotype UNIQUE Text // Zygosity Rearrangement ?Rearrangement XREF Component_of_genotype UNIQUE Text // Zygosity Transgene ?Transgene XREF Component_of_genotype UNIQUE Text // Zygosity // Zygosity text entry should be one of the following: // Homozygous, Heterozygous_with_wildtype, or Heteroallelic_combination Other_component UNIQUE ?Text // Free text components including RNAi Disease_info Models_disease ?DO_term XREF Disease_model_genotype Modifies_disease ?DO_term XREF Disease_modifier_genotype Disease_model_annotation Model_genotype ?Disease_model_annotation XREF Genotype Modifier_genotype ?Disease_model_annotation XREF Modifier_genotype Species UNIQUE ?Species Remark ?Text Reference ?Paper XREF Genotype