Disease and Drugs

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C. elegans as a model system to study disease and disease genes

Human disease gene orthologs in elegans

Human disease relevance descriptions

Human disease relevance descriptions were introduced in late 2011, on the WormBase gene page, to serve both the worm researcher and the biomedical researcher from outside the worm community. This description alerts researchers to the fact that the worm is either an effective model system or is being developed as a model system to study the disease/gene. They are written in most cases, to include the following information:

  • Orthology to the human disease gene or family of genes, may include domain information.
  • The different types of human diseases known to have mutations in the human gene ortholog. OMIM accession numbers are provided below the description which are links into the OMIM resource.
  • Functional similarities or differences between the human/vertebrate and worm gene.
  • Data from worm studies that add new knowledge, or validate existing knowledge from studies in other species or experimental systems (eg., cell culture, etc.).

C. elegans as a model for infection

C. elegans as a model to study biofilms

Using C. elegans to study the effects of space flight

C. elegans as a model system to study drugs

C. elegans is being used to:

  • study the effects of a drug/chemical on disease phenotypes
  • identify gene targets for a given drug/chemical
  • mode of action of a drug/chemical (MOA)

Types of drugs being studied include:

  • Antifungal agents
  • Antimicrobial agents

Textpresso-based systems to flag papers for disease gene ortholog/disease/drug

Pipeline for identifying papers with disease or disease gene ortholog