View source for C. elegans models for human disease in the literature

'''1. Neuromuscular diseases:'''

Amyotrophic Lateral Sclerosis, Duchenne Muscular Dystrophy, Friedreich’s Ataxia, Inclusion Body Myositis, Spinal Muscular Atrophy 
*Human genes: SOD1, TDP43, DMD, FXN, APP, SMN 
*elegans counterparts: sod-1, tdp-1, dys-1, frh-1, apl-1, smn-1)

'''2. Complex neurological diseases:'''

*Parkinson’s disease: modeling via transgenic expression of human genes alpha-synuclein (PARK1);  *Genes involved: leucine-rich repeat kinase 2 (LRRK2, also known as PARK8); ubiquitin E3 ligase (PARK2); kinase PINK1 (PARK6); oncogene DJ-1 (PARK7);  Elegans model also used to study neurotoxic and neuroprotective compounds.
*Alzheimer’s disease and Tauopathies:  
*Human genes APP, PSEN1, PSEN2 and MAPT gene encoding tau
*elegans apl-1, elegans presenilins-sel-12, hop-1, spe-4 ; elegans effectors of  transgenic expression of tau: sut-1, sut-2.
*Autism spectrum disorders: Human Shank family proteins, neuroligins, neurexins;
Elegans: shn-1, nlg-1, nrx-1.

'''3.  Ciliary diseases:''' 

Cystic kidney dieases: Polycystic kidney disease (PKD) 
*Human genes PKD1, PKD2. 
Elegans: lov-1, pkd-2 

Autosomal recessive  polycystic kidney disease
*Human Genes Tg737orpk, hetrotrimeric kinesin-II, KIF3A, KIF17 
*Elegans: osm-5, klp-11, klp-20, kap-1, osm-3; 

Bardet-Biedl syndrome 
*human genes-BBS genes
*Elegans: bbs genes 

Nephronophthisis
*human genes-NPHP1, NPHP2, NPHP3, NPHP4 
*elegans genes: M28.7, T28D6.4, klc-1, klc-2, R13H4.1.

'''4. Laminopathic diseases:''' 

Mutations in lamin (LMNA) cause:
Emery-Dreifuss muscular dystrophy (EDMD) 
*human gene: Emerin 
*elegans: emr-1

LMNA-related congenital muscular dystrophy (L-CMD)

Limb-girdle muscular dystrophy and dilated cardiomyopathy

Neuropathic Charcot-Marie-Tooth disorder

Lipodystrophies: Mandicyloacral  dysplasia, Dunnigan-type familial partial lipodystrophy

Systemic premature aging syndromes: Hutchison-Gilford progeria, Werner syndrome

'''5. Intestinal inflammatory diseases:'''

Ulcerative colitis

Crohn’s disease

Necrotizing enterocolitis (NEC)

Human gene: Toll-like Receptor 4 (TLR4)


'''6. Obesity'''

'''7. Prion diseases'''
====C. elegans as a model to study infectious agents====
=====Bacteria and Biofilms=====
=====Parasitic nematodes=====
=====Fungal pathogens=====
*human fungal pathogen Cryptococcus neoformans

Textpresso keyword search 'Cryptococcus neoformans' returns 117 documents

====C. elegans as a model to study metal toxicity and detoxification====

====Using C. elegans to study the effects of space flight====