Brugia malayi

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Brugia malayi is a gonochoristic (male-female) filarial parasite, of medical interest because it infects mosquito vectors (Aedes,Anopheles, and Culex) and humans, and is phylogenetically representative of other infectious nematodes. Infection of humans by B. malayi causes filariasis.

It has the following Web resources:

1. An article describing its genomic sequence.

2. A genome browser gateway for the current assembly at WormBase.

3. A review of nematode phylogeny from WormBook.

4. Information on B. malayi from the Blaxter laboratory.

5. Information on filariasis from the CDC.

6. In silico predictions of possible drug targets in B. malayi.

7. Genomic data from the nematode sequencing project at the Washington University Genome Sequencing Center.

8. Genomic data from the Sanger Institute.

9. An article in Wikipedia.

NOTE: WormBase is a scientific database for experimental work on C. elegans and other laboratory nematodes: it is not a resource for medical information, it is not run or staffed by clinicians, and it should not be used as a source of advice on parasitic nematode infections. If you need such advice, please contact a qualified physician, preferably one trained in parasitic diseases.

December 2010

WormBase currently shows a merged gene set.

The Transcripts with ids like Bm1_57650A are from the original TIGR data, and the ones with ids like BMAL5.1 are from Erich Schwartz's Augustus prediction set.

We merged overlapping transcripts on the same strand into genes, and removed isoforms, that are substrings of another one (based on 100% DNA and exon boundary identity, and no internal stops in the larger isoform).