Drugs

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C. elegans as a model system to study drugs

C. elegans is being used to study:

  • metal toxicity and detoxification
  • the effects of a drug/chemical on disease phenotypes
  • identify gene targets for a given drug/chemical
  • mode of action of a drug/chemical (MOA)

Types of drugs being studied include:

  • Antifungal agents
  • Antimicrobial agents
  • Antiparasitic drugs--Aldicarb, Ivermectin, Levamisole
  • Anti-depressants--Fluoxetine, Imipramine
  • Anaesthic--Halothane
  • Anticancer drugs--Farnesyltransferase inhibitors (FTIs)
  • Anticonvulsants--Ethosuximide, Arimethadione
  • Alkaloid drugs--Nicotine
  • Immunosuppressants--Prednisone
  • Nutritional supplements--Resveratrol, Gingko biloba
  • Opioid toxins--MPTP/MPP+
  • Pychoactive drug--Ethanol